South San Francisco, CA

Scientist I/II

Summary and Scope:

The ideal candidate possesses a strong work ethic and collaborative spirit with a broad background in biochemistry and molecular biology and will have excellent laboratory skills in protein biochemistry, enzymology, cell biology and biophysical techniques. This position will also have direct experience with high throughput screening and/or ligand-directed small molecule lead development. This is a laboratory-based position within a fast-paced Research & Development (R&D) team responsible for developing and utilizing biochemistry assays and tools to evaluate, select and advance small molecule drugs that target the immune response. S/he/they will develop and perform kinetic and mechanistic assays to identify and validate hit compounds and to characterize enzyme activity and mechanism of action of inhibitors and antagonists of immune targets towards selection of lead compounds for advancement. The candidate will also develop biochemical and cellular assays to support early discovery and biomarker development of clinical drug candidates.


(duties are not limited to the below and may evolve over time and change depending on business needs and individual expertise)

  • Responsible for the design, development and performance of enzymatic, biochemical, biophysical and cell-based assays for high throughput assay screening and for hit-to-lead small molecule drug discovery activities
  • Design, clone and express proteins in E.coli or other eukaryotic protein expression systems
  • Purify proteins using affinity tag and conventional chromatography
  • Characterize protein-ligand interactions using analytical methods such as ITC to measure dissociation constants
  • Desire to learn and perform new techniques in immunology, biochemistry and molecular biology
  • Analyze, document and report data in accordance with company requirements. 
  • In collaboration with manager, interpret and summarize experimental data
  • Present experimental results at group meetings and scientific conferences
  • Actively contribute to project teams and work effectively across functional teams to help advance programs

Education & Experience

  • PhD and Post-Doctoral studies in biochemistry and/or immunology, or PhD with a minimum of 2 years of industry experience
  • Expertise in mechanistic enzymology, enzyme kinetics, enzyme assay development
  • Solid experience with high throughput screening campaigns and hit-to-lead SAR activities preferred
  • Experience with structural biology-based small molecule design preferred
  • Understanding and/or interest in immunology and innate immunity preferred 
  • Experience managing external collaborations/vendors is preferred
  • Excellent communication skills, both written and verbal

Knowledge, Skills & Abilities

  • Strong interpersonal, communication, and problem-solving skills 
  • Strong organizational and effective time management skills; ability to meet tight deadlines 
  • Ability to handle multiple tasks and changing priorities 
  • Proficiency with Microsoft Office suite (Excel, Word, Sharepoint), PRISM, flow cytometry analysis, electric lab notebook, and database software. 
  • Prior LIMS experience a plus
  • Ability to function at a high level in a team setting as an individual contributor
  • Sound judgment and critical thinking skills
  • Highly detail oriented and meticulous with data

Tempest Guiding Principles

  1. Be Respectful and Collaborate
  2. Work with Integrity and Rigor
  3. Commit to Personal and Corporate Growth
  4. Strive for Success

About Tempest Therapeutics: 

Tempest Therapeutics is a clinical-stage oncology company advancing small molecules that combine both targeted and immune-mediated mechanisms with the potential to treat a wide range of tumors.

The company’s two novel clinical programs are TPST-1495 and TPST-1120, antagonists of EP2/EP4 and PPARα, respectively. Both TPST-1495 and TPST-1120 are advancing through Phase 1 studies designed to study both agents as monotherapies and in combination with other approved agents.

Tempest is also developing an inhibitor of TREX-1, a double-stranded DNA exonuclease that is designed to control activation of the cGAS/STING pathway, which is an innate immune response pathway that induces the production of IFN-β, a cytokine that is well-established to trigger the development of anti-tumor immunity. Oral delivery of a TREX-1 small molecule inhibitor is intended to selectively activate STING in tumors, leading to anti-tumor immunity.

Tempest is headquartered in South San Francisco and supported by notable healthcare investors. More information about Tempest can be found on the company’s website at

Tempest Therapeutics, Inc. offers a competitive salary and benefits package. Qualified candidates should forward a resume and cover letter to:

This is not a remote position. Local candidates only, relocation is not provided.

Tempest Therapeutics, Inc. is an Equal Opportunity Employer and all applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.