South San Francisco, CA

Associate Scientist/Scientist

The ideal candidate is a self-motivated, energetic, and detail-oriented Ph.D with significant exposure to immunology and oncology research or significant prior experience within a fast-paced Research & Development (R&D) team. The primary role for the candidate is to define immunological and biological mechanisms of action for discovery stage targets and drug candidates and to enact preclinical methodologies to advance the understanding and direction of clinical stage programs. In line with these goals, the successful candidate will employ methodologies that span immunology, biochemistry, and molecular biology to effectively execute in vitro and in vivo experiments. She/he/they will support projects from early development and will have the opportunity to work in a cross functional environment, interacting with discovery, chemistry, and clinical teams, and participating in IND-enabling activities. The candidate must be driven, resourceful, and able to work independently. The candidate will utilize excellent organizational skills and leverage their previous experience to thoughtfully formulate hypotheses, address these hypotheses through experimentation, and present organized data and conclusions to the company. Teamwork, collaboration with colleagues across disciplines, and communication skills are critical. The position will report to our Senior Scientist and Program Leader, Immunology and in vivo Biology.

Responsibilities

(not limited to the below and may evolve over time and change depending on business needs and individual expertise): 

  • Work with manager and team to synthesize direction of projects, formulate hypotheses, and carry out experiments with diligence to obtain reproducible results. 
  • Apply routine in vivo and in vitro immune and cellular assays (ELISA, Luminex, western blots, flow cytometry, etc.) to enable drug candidate evaluation to understand mechanism of action.
  • Process and utilize tissue samples from human blood or PBMC and ex vivo murine experiments.
  • Manage outsourced work and communicate effectively with contract research organizations to ensure experimentation is performed accurately with adherence to timelines. 
  • Analyze and interpret data logically to inform project.
  • Represent team and present data at cross-functional project team meetings.
  • Accurately document all protocols, experimental data, and results in appropriate electronic lab notebooks with accuracy and in a timely fashion.
  • Collaborate daily with teammates and contribute to daily laboratory activities to ensure functionality of teams (including procurement and organization).

Education & Experience

  • Ph.D. or equivalent in Biology/Immunology or related major in the Life Sciences  
  • At least 5-7 years laboratory (academia or industry) research experience
  • Experience with relevant sample and model types (human biological samples, mouse tumor and lymphoid tissues)
  • Experience with standard immune assays (ELISA, Flow cytometry, qPCR, Western Blot) 
  • Experience with animal modelling of human disease
  • Publication record is desired
  • Molecular biology experience beneficial 

Knowledge, Skills and Abilities

  • Strong interpersonal, communication, and problem-solving skills 
  • Ability to meet tight deadlines using strong organizational and time-management skills
  • Ability to handle multiple tasks and changing priorities 
  • Proficiency with Microsoft Office suite (Excel, Word), PRISM, Flow Cytometry analysis software (FlowJo, Cytobank) and database software
  • Ability to function as an individual contributor in a team setting
  • Sound judgment and critical thinking skills
  • Highly detail-oriented and meticulous with data 

Tempest Guiding Principles

  • Be Respectful and Collaborate
  • Work with Integrity and Rigor
  • Commit to Personal and Corporate Growth
  • Strive for Success

About Tempest Therapeutics

Tempest Therapeutics is a clinical-stage oncology company advancing small molecules that combine both targeted and immune-mediated mechanisms with the potential to treat a wide range of tumors.  
 
The company’s two novel clinical programs are TPST-1495 and TPST-1120, antagonists of EP2/EP4 and PPARα, respectively. Both TPST-1495 and TPST-1120 are advancing through Phase 1 studies designed to study both agents as monotherapies and in combination with other approved agents.  
 
Tempest is also developing an inhibitor of TREX-1, a double-stranded DNA exonuclease that is designed to control activation of the cGAS/STING pathway, which is an innate immune response pathway that induces the production of IFN-β, a cytokine that is well-established to trigger the development of anti-tumor immunity. Oral delivery of a TREX-1 small molecule inhibitor is intended to selectively activate STING in tumors, leading to anti-tumor immunity.  

Tempest is headquartered in South San Francisco and supported by notable healthcare investors. It is publicly traded on the NASDAQ under the ticker symbol TPST. More information about Tempest can be found on the company’s website at www.tempesttx.com

Tempest Therapeutics, Inc. offers a competitive salary and benefits package. Qualified candidates should forward a resume and cover letter to: careers@tempesttx.com

This is not a remote position. Local candidates only, relocation is not provided.

NO PHONE CALLS or AGENCIES Please.

Tempest Therapeutics, Inc. is an Equal Opportunity Employer and all applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Tempest Therapeutics, Inc. (Tempest) anticipates the base salary for the Associate Scientist/Scientist in our Brisbane, CA office to range from $103,000 to $129,000 and will depend on current market data and the candidate’s qualifications for the role, including education and experience. The compensation described above is subject to change and could be higher or lower than the range described based on several factors.