South San Francisco, CA
Associate Scientist / Sr. Research Associate
The ideal candidate is a self-motivated, energetic, detail-oriented Associate Scientist with broad immunology and immunoassay experience preferably in both mouse and human in vitro/in vivo systems, along with prior experience within a fast-paced Research & Development (R&D) team. The primary role for the candidate is developing and optimizing cellular assays, testing in vivo tumor efficacy of various agents in development and supporting Tempest R&D efforts including drug candidate selection, preclinical evaluation, and analysis of patient samples from clinical trials. Experience with molecular biology techniques is desirable.
The successful candidate will contribute to the design and execution of proof of concept and validation assays. S/he will support projects from early development and will have the opportunity to work in a cross functional environment, including participating in IND-enabling activities.
The candidate must be driven, resourceful, and able to work independently. Excellent organizational skills in management of data, reagents and formulate conclusion. Teamwork, collaboration with colleagues across disciplines and excellent verbal and written communication skills are critical. The position will report to a Senior Scientist.
(duties are not limited to the below and may evolve over time and change depending on business needs and individual expertise)
- Oversee in vivo tumor efficacy studies to include comprehensive analyses of drug induced immune responses in periphery and TME
- Design and apply routine immune and cellular assays (ELISA, Luminex, PBMC Processing, molecular) to enable drug candidate evaluation to include mechanism of action
- Develop and optimize biological assays to support drug candidate selection
- Represent team and present data at cross-functional project team meetings
- Plan, execute and troubleshoot experiments to support advancement of projects.
- Isolation, phenotypic and functional characterization of primary human cells.
- Design and maintain multi-parameter flow cytometry panels
- Analyze and interpret data and draw conclusions to help decide next steps.
- Accurately document all protocols, experimental data and results in appropriate electronic lab notebooks with accuracy and timelines.
- Contribute to daily laboratory activities (including procurement and organization)
Education & Experience
- BS or above in Biology/Immunology or related major in the Life Sciences. Masters a plus. Individual experience will determine level
- At least 5-7 years laboratory (academia or industry) research experience.
- Experience working under SOPs is beneficial
- Experience with relevant sample and model types (human biological samples, mouse)
- Molecular biology experience beneficial
- Solid knowledge with standard immune assays (ELISA, Flow cytometry, Luminex)
- Co-authorship of peer reviewed publications, patents and presentations are considered a plus
Knowledge, Skills and Abilities
- Strong interpersonal, communication, and problem-solving skills
- Strong organizational and effective time management skills; ability to meet tight deadlines
- Ability to handle multiple tasks and changing priorities
- Proficiency with Microsoft Office suite (Excel, Word), PRISM and database software.
- Prior LIMS experience a plus
- Ability to function at a high level in a team setting as an individual contributor
- Sound judgment and critical thinking skills
- Highly detail oriented and meticulous with data
Tempest Guiding Principles
- Be Respectful and Collaborate
- Work with Integrity and Rigor
- Commit to Personal and Corporate Growth
- Strive for Success
Tempest Therapeutics, Inc. offers a competitive salary and benefits package. Qualified candidates should forward a resume and cover letter including a statement of interest to: firstname.lastname@example.org
PLEASE, NO PHONE CALLS or AGENCIES
Tempest Therapeutics, Inc. is an Equal Opportunity Employer and all applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.